Mucoadhesive films of Metronidazole (MTZ) were formulated in order to achieve the high bioavailability and effective treatment for periodontal diseases. The films were prepared at different pH’s (5, 7&10) containing dispersions of sodium alginate (SA), magnesium aluminum silicate (MAS) with MTZ by solvent evaporation technique. The films were characterized for surface morphology, MTZ content; Invitro release rate, bioadhesion, and its permeation across the mucosal membrane were investigated. It reveals that the MTZ loaded SA-MAS films prepared at pH 5 yields not only high content of MTZ but also shows a good bioadhesive property for adhesion to mucosal membrane. More over at pH 5 the formation of MTZ-MAS complexes which acts as micro reservoirs of the films having the positive influence on MTZ content & release rate. These findings shows that through buccal delivery system the MTZ loaded SA-MAS films (with no. of MTZ-MAS complexes as microreserviors) having a strong potential for the treatment of periodontal diseases through buccal delivery system.
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